microscopic view of an animal cell

CAMPOS Research Colloquia

The Center for the Advancement of Multicultural Perspectives on Science is pleased to announce the CAMPOS Research Colloquia. The Research Colloquia showcase the fantastic research done by CAMPOS scholars and aims to continue building a diverse scientific community in STEM at UC Davis. 

There are currently 31 CAMPOS Scholars at UC Davis, with appointments spanning 28 departments in 8 colleges and schools. The Colloquia are typically held on the main campus, with one or two per quarter at the UC Davis Medical Center. Due to the COVID-19 crisis and subsequent campus lockdown, the colloquia will be held online until further notice. Please contact mgalindovega@ucdavis.edu for zoom link information.

Direct any inquiries to Mariel Vazquez, CAMPOS Faculty Director, mrlvazquez@ucdavis.edu, or to Mariana Galindo-Vega

May 27, 2021 | 3:10PM

Lillian Cruz-Orengo, Assistant Professor, Anatomy, Physiology, and Cell Biology

head shot of Lillian Cruz-Orengo
“The Great Wall Under Siege! Role of IL-20 sub-family cytokines at the blood-brain barrier during neuroinflammation”

Email Mariana Galindo-Vega for Zoom link

[Faculty Page]

Central nervous system (CNS) homeostasis is largely maintained by the blood-brain barrier (BBB) that halts the entry of noxious substances and immune cells. Consequently, a breach to the BBB triggers the neuroinflammatory processes that underlie many, if not all, neurologic disorders with significant morbidity and mortality worldwide. It has been known that VEGF activity alters the BBB by enhancing its permeability. It is known that immune extravasation mediated by alterations in apicobasal polarity of CXCL12 causes neuroinflammation. However, it is not clear how these two processes are connected. Our laboratory aims to elucidate the role of the cytokine subfamily IL-20 linking BBB enhanced permeability and immune extravasation. Understanding this link is essential for the development of novel therapeutic approaches towards neuroinflammation.